Atelier 273 - Applications thérapeutiques des vésicules extracellulaires
Lundi 12 Juin 2023 ◘ Monday, June 12, 2023 |
|
| 15:00 - 15:30 | Reception of participants |
| 15:30 - 15:45 | Welcome and presentation by the organizers |
| 15:45 - 16:30 | Introduction conference: EVs, from cell dust to magic bullet? Insights and perspective on a translational ongoing experience |
| Philippe MENASCHÉ (HEGP, Paris, France) | |
| SESSION I | Deciphering the mechanism(s) of action of EVs |
| 16:30 - 17:15 | How EVs interact with cell and deliver their cargo? |
| Grégory LAVIEU (MSC, Paris, France) | |
| 17:15 - 17:45 | Coffee break |
| 17:45 - 18:30 | Biodistribution : How long and how far EVs circulate in the body? RNA transfer : Myth or reality? |
| Pieter VADER (UMC Utrecht, Netherlands) | |
| 18:30 - 19:15 | Predictive models and potency assays |
| Danièle NOËL (IRMB, Montpellier, France) | |
| 19:15 - 20:15 |
Round table: How diverse and dynamic EVs are? Benefit and pitfalls The risk of purity: EV-enriched secretome, EV-like, false and bona fide EV, Separating EV subpopulation |
| 20:15 | Dinner |
Mardi 13 Juin 2023 ◘ Tuesday, June 13, 2023 |
|
| 06:30 - 08:30 | Breakfast |
| SESSION II | Which EVs for which purpose? Engineering and optimization |
| 08:30 - 09:15 | EV engineering and loading |
| Marie MORILLE (ICGM, Montpellier, France) | |
| 09:15 - 10:00 | Modulating EV identity or secretome content? optimizing EV activity? Hit to lead approach |
| Max PIFFOUX (CHU Lyon, France) | |
| 10:00 - 10:30 | Coffee break |
| 10:30 - 11:15 | Immunomodulation using EVs |
| Jean-Marie BACH (ONIRIS, Nantes, France) | |
| 11:15 - 12:00 |
Round table: Diversity of cell sources (eukaryote, prokaryote, plant...) EV-like, hybrids and other subcellular therapies (mitochondria, virus, etc..) |
| 12:00 - 14:00 | Lunch |
| SESSION III | Which indications to go to the clinic? |
| 14:00 - 14:45 | EV for the delivery of active agents to the CNS |
| Anne DES RIEUX (Université catholique de Louvain, Belgium) | |
| 14:45 - 15:30 | Kidney regeneration |
| Benedetta BUSSOLATI (DBMSS, Torino, Italy) | |
| 15:30 - 16:15 | Acute inflammation and organ failure |
| Antoine MONSEL (CHU Pitié Salpétrière, Paris, France) | |
| 16:15 - 16:45 | Coffee Break |
| 16:45 - 17:30 | Engineering of Extracellular Vesicles for targeted delivery of biotherapies |
| Samir EL ANDALOUSSI (Karolinska Institute, Sweden) | |
| 17:30 - 18:15 | Enzyme replacement therapy |
| Ibane ABASOLO (CIBBIM, Barcelona, Spain) | |
| 18:15 - 19:00 | Organ Protection (organ graft, ischemia/reperfusion, stroke) |
| Sara MARTINEZ DE LIZARRONDO (Cyceron, Caen, France) | |
| 19:30 - 20:15 | Cocktail |
| 20:15 | Dinner |
Mercredi 14 Juin 2023 ◘ Wednesday, June 14, 2023 |
|
| 06:30 - 08:30 | Breakfast |
| SESSION IV | Nanometrology and machine learning approaches |
| 08:30 - 09:15 | Multimodal characterization toolbox, standardization and nanometrology |
| Céline ELIE CAILLE (FEMTO-ST, Univ. Franche Comté, France) | |
| 09:15 - 10:00 | Characterizing / modifying EV identity and activity : machine learning for analytical validation |
| Kelly AUBERTIN and Alice GRANGIER (MSC, IVETh, Paris, France) | |
| 10:00 - 10:30 | Coffee Break |
| SESSION V | Industrial hurdles : Bioproduction, quality control, toxicology, regulatory issues |
| 10:30 - 11:15 | EV bioproduction, scale up and industrial work flow |
| Jeanne VOLATRON (Everzom, Paris, France) | |
| 11:15 - 12:00 | Formulation, quality control, GMP procedure, Regulatory issues |
| Amanda SILVA BRUNS (MSC, Paris, France) | |
| 12:00 - 12:45 | First in man and design of clinical trials |
| Sebastien BANZET (CTSA, Villejuif, France) | |
| 12:45 - 14:30 | Lunch |
| 14:00 | Departure |