Ateliers Inserm 2023 - INSERM

Ateliers Inserm 2023

Atelier 274 - Essais randomisés en cluster et essais randomisés intra-patient : aspects statistiques, pratiques et éthiques

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Mercredi 21 Juin 2023  ◘ Wednesday, June 21, 2023

15:30 - 16:00 Reception of participants
16:00 - 16:15 Welcome and presentation by the organizers

SESSION I

Cluster randomized trials: planning, conduct and analysis

16:15 - 17:00 Generalities: what is a cluster randomized trial? When should we cluster randomize? For which kind of intervention?
Sandra ELDRIDGE (Queen Mary University of London, United Kingdom)
17:00 - 17:30 Coffee break
17:30 - 18:15 Designs in cluster randomized trials: parallel or not? Complete or incomplete? Baseline data or not? Equal or unequal allocation?
Andrew COPAS (University College London, United Kingdom)
18:15 - 19:00 Sample size calculation in different cluster randomized designs
Monica TALJAARD (Ottawa Hospital Research Institute, Canada)
19:30 Dinner
   

Jeudi 22 Juin 2023 ◘ Thursday, June 22, 2023

06:30 - 08:30  Breakfast
08:30 - 09:15 Small number of clusters: planning, analysis
Clémence LEYRAT (London School of Hygiene and Tropical Medicine, United Kingdom)
09:15 - 10:00 Risk of bias in cluster randomized trials
Sandra ELDRIDGE & Bruno GIRAUDEAU (Queen Mary University of London, United Kingdom - University of Tours & INSERM U1246)
10:00 - 10:30 Coffee break
10:30 - 11:15 Statistical analysis of a cluster randomized trials: cluster-level analysis, individual level analysis, missing data, intraclass correlation estimation
Elisabeth TURNER (Duke University, USA)
11:15 - 12:00 Ethical issues in cluster randomized trials
Charles WEIJER (Western University, London, Canada)
12:00 - 14:00 Lunch

SESSION II

Cluster randomized cross-over trials and stepped-wedge cluster randomized trials

14:00 - 14:45 Specificities of cluster randomized cross-over trials
Andrew FORBES (Monash University, Melbourne, Australia)
14:45 - 15:30 Stepped-wedge cluster randomized trials: general issues
Karla HEMMING (University of Birmingham, United Kingdom)
15:30 - 16:00 Coffee Break
16:00 - 16:45 Analysis of a stepped-wedge cluster randomized trial
Andrew COPAS (University College London, United Kingdom)
16:45 - 17:30 Correlation structure in cluster randomized cross-over and stepped-wedge cluster randomized trials
Jessica KASZA (Monash University, Melbourne, Australia)

SESSION III

Practical issues

17:30 - 18:15 Practical issues: lessons from several years of experience
Laurent BILLOT (The George Institute for Global Health, Sydney, Australia)
19:30 - 20:15 Cocktail
20:15 Dinner
   

Vendredi 23 Juin 2023 ◘ Friday, June 23, 2023

06:30 - 08:30 Breakfast
08:30 - 09:15 Challenges in stepped-wedge cluster randomized trials
Agnès CAILLE (University of Tours & INSERM U1246)

SESSION IV

Within person randomized trials

09:15 - 10:00 Within-person randomized trial: general issues and reporting
Nikolaos PANDIS (University of Berne, Switzerland)
10:00 - 10:30 Coffee Break
10:30 - 11:15 Within-person randomized trial in dermatology: planning and analysis
Sophie LEDUCQ (University of Tours & INSERM U1246)
11:15 - 12:00 Within-person randomized trial in dentistry
Emmanuel LESAFFRE (KU Leuven University, Belgium)
12:00 - 14:00 Lunch
14:00 Departure

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