Atelier 281 - Données génomiques massives : avancées statistiques et bioinformatiques
Lundi 16 Septembre 2024 - Monday, September 16, 2024 |
|
|
14:30 - 15:00 |
Reception of participants |
| 15:00 - 15:30 | Welcome and presentation by the organizers |
| SESSION I | From exome to whole-genome sequencing |
| 15:30 - 16:15 | Successes in monogenic diseases |
| Christel Depienne (University of Essen, Germany) | |
| 16:15 - 17:00 | Success and challenges from NGS data in deciphering underlying mechanisms of multifactorial traits |
| Inês Barroso (University of Exeter, UK) | |
| 17:00 - 17:30 | Coffee break |
| 17:30 - 18:15 | The non-coding genome |
| Benoit Ballester (Inserm U1090/Aix-Marseille Université, Marseille, France) | |
| 18:15 - 19:00 | Pangenome as a reference genome & the implication for future method developments |
| Jean Monlong (Inserm U1220, Toulouse, France) | |
| 19:30 | Dinner |
Mardi 17 Septembre 2024 - Tuesday, September 17, 2024 |
|
| 06:30 - 08:30 | Breakfast |
| SESSION II | Methodological developments… |
| 08:30 - 09:15 | Beyond SNVs & indels: structural variations, transposable elements |
| Jean Muller (Université de Strasbourg, France) | |
| 09:15 - 10:00 | Phasing & imputation, including rare variants, structural variants & issues with large biobanks |
| Simone Rubinacci (Harvard medical school/Broad institute, Boston, USA) | |
| 10:00 - 10:30 | Coffee break |
| 10:30 - 11:15 | Rare variants association tests, in coding and non-coding |
| Ozvan Bocher (Helmholtz Center, Munich, Germany) | |
| 11:15 - 12:00 | Fine mapping: functional annotations, trans-ancestry and multi-trait similarity |
| Jenn Asimit (University of Cambridge, United Kingdom) | |
| 12:00 - 14:00 | Lunch |
| SESSION III | … Methodological developments |
| 14:00 - 14:45 | Multi-omics data integration |
| Anaïs Baudot (Inserm U1251/CNRS, Marseille, France) | |
| 14:45 - 15:30 | Epistasis and GxE analysis |
| Hugues Aschard (Institut Pasteur, Paris, France) | |
| 15:30 - 16:00 | Coffee Break |
| 16:00 - 16:45 | Polygenic risk scores (PRS) in the clinic |
| Fabienne Lesueur (Inserm U900/Institut Curie, Paris, France) | |
| 16:45 - 17:30 | Pros and cons of PRS and the underlying assumptions of GWAS |
| Anthony Herzig (Inserm U1078, Brest, France) | |
| 19:30 - 20:15 | Cocktail |
| 20:15 | Dinner |
Mercredi 18 Septembre 2024 - Wednesday, September 18, 2024 |
|
| 06:30 - 08:30 | Breakfast |
| SESSION IV | Data sharing & ethics |
| 08:30 - 09:15 | Large sequencing projects: POPGEN, Genomic Medicine France, Genome Europe |
| Emmanuelle Génin (Inserm U1078, IT Génétique-Génomique-Bioinformatique, Paris, France) | |
| 09:15 - 10:00 | Federated learning: sharing the methods and not the data |
| Aurélien Bellet (Inria, Lille, France) | |
| 10:00 - 10:30 | Coffee Break |
| 10:30 - 11:15 | Services deployed by the Institut Français de Bioinformatique (IFB) for massive genomic data projects |
| Jacques Van Helden (Aix-Marseille Université/IFB/ELIXIR-FR, Marseille, France) | |
| 11:15 - 12:00 | Ethic issues with collecting and analyzing massive health data, including genomics |
| Catherine Bourgain (Inserm U988/CNRS/EHESS/Université Paris Cité, Paris, France) | |
| 12:00 - 14:00 | Lunch |
| 14:00 | Departure |